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1,4-Dioxane

CAS 123-91-1C4H8O288.11 g/mol

1,4-dioxane is a dioxane with oxygen atoms at positions 1 and 4. It has a role as a metabolite, a non-polar solvent and a carcinogenic agent. It is a volatile organic compound and a dioxane.

IUPAC: 1,4-dioxane

1,4-Dioxane molecular structure

PubChem

Physical & Chemical Properties

Physical and chemical properties
Melting Point53.2 °F (NTP, 1992)
Boiling Point214 °F at 760 mmHg (NTP, 1992)
Density1.036 at 68 °F (USCG, 1999) - Denser than water; will sink
Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Flash Point54 °F (NTP, 1992)
Vapor Pressure29 mmHg at 68 °F ; 37 mmHg at 77 °F (NTP, 1992)
AppearanceDioxane appears as a clear colorless liquid with a faint ethereal odor. Flash point 55 °F. Slightly denser than water and soluble in water. Vapors heavier than air. Susceptible to autooxidation to form peroxides.

Data: PubChem · Last updated: 4/20/2026

GHS Classification

No GHS classification data available.

Classification data is sourced from ECHA.

Regulatory Compliance

TSCA

Listed

note: Status based on EPA TSCA Active Inventory · inventory name: TSCA Chemical Substance Inventory

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SVHC

Not Listed

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FDA GRAS

Not Listed

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No trade flow data available for this chemical.

HS Code(s): 2932

Data: UN Comtrade

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